MechanismType: Mechanism Type for nucleophilic substitution or elimination
The nucleophilic substituion can be largely into two types: SN1 (dissociative) and SN2 (associative).
“Concerted reaction/mechanism” also indicates SN2 reaction type, as all bonds are formed and broken in concert.
The mutant sialidases operate by a dissociative mechanism, and the wild-type enzyme operates by a concerted mechanism.
T1 Enzyme 4 21 mutant sialidases
T2 NucleophilicAttack 35 57 dissociative mechanism
T3 Enzyme 67 83 wild-type enzyme
T4 NucleophilicAttack 98 117 concerted mechanism
E1 NucleophilicAttack:T2 Agent:T1
E2 NucleophilicAttack:T4 Agent:T3
A1 EnzymeAttribute T1 mutant
A2 EnzymeAttribute T3 Wild-type
A3 MechanismType E1 Dissociative
A4 MechanismType E2 Associative