group_member: Relation between a countable set and its element; group and member

This relation describes relationships between a group and its members.

Tyr150/Tyr210 as the residues involved in substrate binding.
T1 AminoAcid 0 6 Tyr150
T2 AminoAcid 7 13 Tyr210
T3 AminoAcid 21 29 residues
T4 EntityProperty 42 51 substrate
T5 Interaction 52 59 binding
E1 Interaction:T5 Theme:T3 Theme2:T4
A1 EnzymeCompoundAttribute T3 Types/family
A2 EntityAttribute T4 ReactionState
R1 group_member Arg1:T3 Arg2:T1
R2 group_member Arg1:T3 Arg2:T2

PPAT belongs to the nucleotidyltransferase superfamily.
T1 Enzyme 0 4 PPAT
T2 Enzyme 20 54 nucleotidyltransferase superfamily
R1 group_member Arg1:T2 Arg2:T1
A1 EnzymeCompoundAttribute T2 Types/family

This relation can be used to describe the relationships between reaction events.

For example, in the following reaction, “acetylation reaction” is composed of two reaction steps, “deprotonation” and “nucleophilic attack”.

The acetylation reaction requires deprotonation of the epsilon-amino group prior to nucleophilic attack.
T1 WholeReaction 4 24 acetylation reaction
T2 Deprotonation 34 47 deprotonation
T3 FunctionalGroup 55 74 epsilon-amino group
T4 NucleophilicAttack 84 103 nucleophilic attack
E1 WholeReaction:T1
E2 Deprotonation:T2 Theme:T3
E3 NucleophilicAttack:T4
R1 group_member Arg1:E1 Arg2:E2
R2 group_member Arg1:E1 Arg2:E3
A1 ReactionType E1 Transfer

The catalytic mechanism involves base-catalyzed attack of water.
T1 WholeReaction 4 23 catalytic mechanism
T2 Deprotonation 33 37 base
T3 NucleophilicAttack 38 54 catalyzed attack
T4 OtherCompound 58 63 water
E1 WholeReaction:T1
E2 Deprotonation:T2 Theme:T4
E3 NucleophilicAttack:T3 Agent:T4
R1 group_member Arg1:E1 Arg2:E2
R2 group_member Arg1:E1 Arg2:E3